Title:
【発明の名称】新規フェノール誘導体及びこれを含有する医薬
Document Type and Number:
Japanese Patent JPH0796507
Kind Code:
B2
Abstract:
Phenol derivatives of the formula I wherein A and B have the same or different meanings and each represent one of the groups -C 3BOND C-, cis-CH=CH- or trans-CH=CH-, R1 is hydrogen, an optionally substituted alkyl or phenyl group or a cycloalkyl group, R2 is hydrogen, methyl or ethyl, R3 represents hydrogen, acetyl or propionyl, R4 has the same meaning as R3 or represents an alkyl group, R5 is a carboxylic or a hydroxy group or a functional derivative of such groups or R5 is a nitrile group and R6 is hydrogen, an alkyl group or the group OR4 which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds are prepared by reacting suitable acetylene compounds or metal derivatives thereof with alkyl or aryl halides or by means of Wittig reactions optionally followed by transforming the member R5 into another carboxylic acid derivative. By hydrogenation A and B may be varied within the scope of the definition.
Inventors:
Oswart Twimmel
Werner Voorenberg
Gerito roussien
Wernel Wintel
Elwin Kiesewetel
Ulrich Zaip
Werner Voorenberg
Gerito roussien
Wernel Wintel
Elwin Kiesewetel
Ulrich Zaip
Application Number:
JP11765686A
Publication Date:
October 18, 1995
Filing Date:
May 23, 1986
Export Citation:
Assignee:
Gryunenta-Le Gezershyaft Mito Besilyen Hafertung
International Classes:
A61K31/16; A61K31/165; A61K31/19; A61K31/22; A61K31/235; A61K31/495; A61K31/535; A61K31/5375; A61P7/00; A61P7/02; A61P9/00; A61P9/12; A61P11/00; A61P29/00; A61P37/08; A61P43/00; C07C27/00; C07C39/18; C07C39/19; C07C39/23; C07C41/00; C07C43/205; C07C43/23; C07C51/00; C07C65/01; C07C65/19; C07C65/28; C07C67/00; C07C69/157; C07C69/88; C07C69/90; C07C219/14; C07C235/60; C07C239/00; C07C253/00; C07C255/54; C07C255/57; C07C259/10; C07D295/18; C07D309/12; C07D317/54; C07F7/18; C07F9/54; C12N9/99; (IPC1-7): C07C39/18; A61K31/16; A61K31/165; A61K31/19; A61K31/22; A61K31/235; A61K31/495; A61K31/535; C07C39/23; C07C43/23; C07C65/19; C07C65/28; C07C69/88; C07C69/90; C07C219/14; C07C235/60; C07C255/54; C07C255/57; C07C259/10; C07D295/18; C07D317/54; C12N9/99
Attorney, Agent or Firm:
Mitsuyoshi Ezaki (1 person outside)