To provide a medicine packaging system capable of easily facilitating a package operation of a packaging sheet and improving piece-packaging speed.

In the medicine packaging system, a partitioned chamber opening toward the upper portion is formed by heat-fused in sequence in the width direction with a longitudinal sealing device while the elongated packaging sheet 2 folded in to two along the lengthwise direction is continuously transferred in the lengthwise direction, a medicine casting inlet 12a of a hopper 12 for casting a medicine is inserted from the upper opening of the partitioned chamber, and the upper opening of the partitioned chamber is continuously heat-fused by a lateral sealing device after casting the medicine from the hopper 12 for casting a medicine. When inserting the hopper 12 for casting a medicine, an opening section is formed to insert the medicine casting inlet 12a of the hopper 12 for casting a medicine at the upper portion of the packaging sheet 2 by adsorbing the packaging sheet 2 folded in to two from right and left with a paper holding body 48.