Title:
MEDICINE OF VINCA DIMER
Document Type and Number:
Japanese Patent JPS56145293
Kind Code:
A
Abstract:
A pharmaceutical formulation which comprises as an active ingredient (VLB or 4-desacetyl VLB) 3-(2-chloroethyl) carboxamide or a pharmaceutically-acceptable acid-addition salt thereof with a pharmaceutically-acceptable carrier therefor. Process for preparing the active ingredient include hydrolyzing the corresponding spirooxozolidinidione, reacting the carboxazide with 2-chloroethylamine, and reacting the 3-(2-hydroxyethyl)-carboxamide with a reagent which facilitates the replacement of a hydroxy function with chlorine and source of chlorine, and optionally, desacetylating; optionally, acetylating; and optimally salifying.
Inventors:
JIYAN SHII MIRAA
JIERARUDO II GUTOBUSUKII
JIERARUDO II GUTOBUSUKII
Application Number:
JP4162781A
Publication Date:
November 11, 1981
Filing Date:
March 20, 1981
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/395; A61K31/475; C07D519/02; A61P35/00; C07D519/04; (IPC1-7): A61K31/475; C07D519/04
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