Title:
プロスタグランジン及びプロスタグランジン類似体をもたらす２−置換−４−オキシ−シクロペント−２−エン−１−オンへのビニルホウ素化合物の金属触媒による非対称１，４−共役付加
Document Type and Number:
Japanese Patent JP6643308
Kind Code:
B2
Abstract:
This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.
Inventors:
Julian Paul Henchiki
Woopin-Yui
Wuxie-Ryan
Wen Wen-Shen
Woopin-Yui
Wuxie-Ryan
Wen Wen-Shen
Application Number:
JP2017500379A
Publication Date:
February 12, 2020
Filing Date:
July 09, 2015
Export Citation:
Assignee:
Sino Farm Taiwan, Limited
International Classes:
C07C405/00; C07F7/18
Domestic Patent References:
| JP2012520294A | ||||
| JP2011518134A | ||||
| JP2014501698A | ||||
| JP2010500351A |
Other References:
Organic Letters,2005年,Vol.7, No.8,1669-1671
Encyclopedia of Reagents for Organic Synthesis,2007年,1-7
Synlett,2002年,5 ,767-768
Tetrahedron,2008年,64,11105-11109
Eur. J. Org. Chem. ,2014年,10 ,2160-2167
Encyclopedia of Reagents for Organic Synthesis,2007年,1-7
Synlett,2002年,5 ,767-768
Tetrahedron,2008年,64,11105-11109
Eur. J. Org. Chem. ,2014年,10 ,2160-2167
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Tatsunori Ikeda
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Tatsunori Ikeda