Title:
METASTIN DERIVATIVES AND USE THEREOF
Document Type and Number:
Japanese Patent JP2013075913
Kind Code:
A
Abstract:
To provide stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.).
By substituting the constituent amino acids of metastin with specific amino acids, the metastin derivatives achieve more improved blood stability, solubility, etc., reduced gelation tendency, improved pharmacokinetics, as well as exhibit an excellent cancer metastasis suppressing activity or a cancer growth suppressing activity. The metastin derivatives also have a gonadotropic hormone secretion suppressing activity, sex hormone secretion suppressing activity, etc.
Inventors:
ASAMI TAIJI
NISHIZAWA NAOKI
NISHIZAWA NAOKI
Application Number:
JP2013004011A
Publication Date:
April 25, 2013
Filing Date:
January 11, 2013
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07K7/02; A61K38/00; A61P3/06; A61P3/10; A61P5/24; A61P15/00; A61P15/06; A61P15/08; A61P25/00; A61P25/28; A61P35/00; A61P35/04; A61P43/00; C07K14/47; C12N15/09
Domestic Patent References:
| JP2004217651A | 2004-08-05 |
Foreign References:
| WO2006001499A2 | 2006-01-05 | |||
| WO2004060264A2 | 2004-07-22 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki
Norio Omori
Yasuhito Suzuki
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