Title:
ジペプチジルペプチダーゼIV阻害剤およびその中間体の製造方法
Document Type and Number:
Japanese Patent JP4896872
Kind Code:
B2
Abstract:
A process for preparing an amine of the structure
which comprises
a. treating an aqueous solution of a keto acid of the structure
with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and
b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions.
Inventors:
Michael politino
Matthew M. Cadin
Paul M. Sconezny
Chen Jason Gee
Matthew M. Cadin
Paul M. Sconezny
Chen Jason Gee
Application Number:
JP2007508513A
Publication Date:
March 14, 2012
Filing Date:
April 13, 2005
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12N9/04; C07H21/04; C12N1/06; C12N1/21; C12N9/02; C12N9/06; C12N15/74; C12P13/04; C12P13/22; C12P15/00; C12P17/10; C12P21/00; C12P21/06; C07C269/04; C07C271/12
Domestic Patent References:
| JP2006516121A | 2006-06-22 | |||
| JPH1023896A | 1998-01-27 | |||
| JP2002520065A | 2002-07-09 | |||
| JP2004525641A | 2004-08-26 | |||
| JP2004511225A | 2004-04-15 | |||
| JP2004520030A | 2004-07-08 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto