Title:
ヒドロキシル基置換生成物の製造方法
Document Type and Number:
Japanese Patent JP5476895
Kind Code:
B2
Abstract:
In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base and a nucleophile (X - ). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active ±-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.
Inventors:
Akio Ishii
Yasumoto Manabu
Koji Ueda
Yasumoto Manabu
Koji Ueda
Application Number:
JP2009225952A
Publication Date:
April 23, 2014
Filing Date:
September 30, 2009
Export Citation:
Assignee:
Central Glass Co., Ltd.
International Classes:
C07C67/307; C07C69/63; C07D207/16; C07B53/00
Foreign References:
| WO2006098444A1 | ||||
| WO2008001718A1 | ||||
| WO2008090755A1 | ||||
| WO2010047266A1 |
Attorney, Agent or Firm:
Makoto Koide