Title:
光学活性2-アリールピペラジン誘導体の製造法
Document Type and Number:
Japanese Patent JP5438976
Kind Code:
B2
Abstract:
The objective of the present invention is to produce an optically active 2-arylpiperazine derivative useful as a synthetic intermediate for pharmaceutical products and agricultural chemicals from inexpensive and readily available starting material by an industrially practicable method. The objective can be accomplished by treating an optically active substituted aminodiol derivative produced from an optically active styrene oxide derivative with a sulfonating agent in the presence of a base, and then reacting an amine compound to obtain the 2-arylpiperazine derivative. Especially, an optically active 1-unsubstituted-2-arylpiperazine derivative can be produced by treating an optically active 1-allyl-2-arylpiperazine derivative with water in the presence of a transition metal catalyst for deallylation.
Inventors:
Masatoshi Onuki
Akira Nishiyama
Masaru Mitsuda
Akira Nishiyama
Masaru Mitsuda
Application Number:
JP2008558049A
Publication Date:
March 12, 2014
Filing Date:
February 05, 2008
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C07D241/04; C07B53/00
Foreign References:
| WO2007035003A1 | 2007-03-29 | |||
| WO2005005410A1 | 2005-01-20 | |||
| WO2007035003A1 | 2007-03-29 |
Other References:
JPN6013018434; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４５, 2002, ｐ．３２８０-３２８５
JPN6013018436; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６２, 1997, ｐ．５１６９-５１７３
JPN6013018436; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６２, 1997, ｐ．５１６９-５１７３
Attorney, Agent or Firm:
Kyuichi Ueki
Tadashi Sugakawa
Hiroaki Ito
Hisahiko Ueki
Tadashi Sugakawa
Hiroaki Ito
Hisahiko Ueki