Title:
光学活性な２，３−ビスホスフィノピラジン誘導体の製造方法及び光学活性なホスフィン遷移金属錯体の製造方法
Document Type and Number:
Japanese Patent JP6682703
Kind Code:
B2
Abstract:
In the method for producing an optically active 2,3-bisphosphinopyrazine derivative of the present invention, an optically active 2,3-bisphosphinopyrazine derivative represented by the following formula (3) is produced by the step of: preparing solution A containing 2,3-dihalogenopyrazine represented by the following formula (1)and a carboxylic acid amide coordinating solvent, lithiating an optically active R- or S-isomer of a hydrogen-phosphine borane compound represented by the following formula (2)to give a lithiated phosphine borane compound; adding solution B containing the lithiated phosphine borane compound to the solution A to perform an aromatic nucleophilic substitution reaction; and then performing a deboranation reaction.(For symbols in the formulas, see the description.)
Inventors:
Daisuke Mayama
Satoshi Takeshita
Ken Tamura
Satoshi Takeshita
Ken Tamura
Application Number:
JP2019529009A
Publication Date:
April 15, 2020
Filing Date:
June 15, 2018
Export Citation:
Assignee:
Nippon Chemical Industry Co., Ltd.
International Classes:
C07F9/6509; C07F1/12
Foreign References:
| WO2011078122A1 | ||||
| WO2011126045A1 |
Attorney, Agent or Firm:
Showa International Patent Office