Title:
精製されたプロスタグランジン誘導体の製造方法
Document Type and Number:
Japanese Patent JP4386581
Kind Code:
B2
Abstract:
A process for producing a purified prostaglandin derivative having a high purity which comprises adding an alkene (1) to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reactant to give an adduct; reacting the adduct with a carboxylic anhydride (4), etc. to give a prostaglandin derivative (6); and then treating the derivative (6) with a nitrogen-containing compound such as 2,2'-bipyridyl to thereby efficiently remove the organic copper reactant employed in the synthesis and by-products derived therefrom.
Inventors:
Masahiro Urushihara
Yoshitomi Morisawa
Yoshitomi Morisawa
Application Number:
JP2000552089A
Publication Date:
December 16, 2009
Filing Date:
June 03, 1999
Export Citation:
Assignee:
Asahi Glass Co., Ltd.
LTT Biopharma Co., Ltd.
MITSUBISHI PHARMA CORPORATION
LTT Biopharma Co., Ltd.
MITSUBISHI PHARMA CORPORATION
International Classes:
C07C405/00
Domestic Patent References:
| JP8119934A | ||||
| JP11302251A | ||||
| JP11279184A | ||||
| JP11180949A |
Foreign References:
| WO1997001534A1 | ||||
| WO1995019340A1 |
Attorney, Agent or Firm:
Kenji Izumina
Toshiharu Ogawa
Ryozo Yamamoto
Tsuyoshi Takahashi
Masakazu Takahashi
Toshiharu Ogawa
Ryozo Yamamoto
Tsuyoshi Takahashi
Masakazu Takahashi