Title:
光学的に純粋なまたは富化されたラセミ体テトラロンの製造方法
Document Type and Number:
Japanese Patent JP2005507935
Kind Code:
A
Abstract:
A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, and a liquid mobile phase preferably containing at least methyl acetate. The liquid mobile phase is preferably free of acetonitrile. The process is operable at temperatures above 40° C.
Inventors:
Berger, Laurent
Raval, Duval
Attireson, Philip
Veber, Ango
Vic, Alexandre
Raval, Duval
Attireson, Philip
Veber, Ango
Vic, Alexandre
Application Number:
JP2003540123A
Publication Date:
March 24, 2005
Filing Date:
September 27, 2002
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07B57/00; C07B63/00; C07C45/78; C07C45/79; C07C49/687; (IPC1-7): C07C45/79; C07C49/687
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto