Title:
ホリニン酸のジアステレオマー塩の製造および分離法
Document Type and Number:
Japanese Patent JP4241925
Kind Code:
B2
Abstract:
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diastereomeric salts.
Inventors:
Felder Ernest
Lipa, The Orgio
Carlo, Distaso
Lipa, The Orgio
Carlo, Distaso
Application Number:
JP50033096A
Publication Date:
March 18, 2009
Filing Date:
May 31, 1995
Export Citation:
Assignee:
Bracco Essepia
International Classes:
C07D475/04; C07B57/00
Domestic Patent References:
| JP56110689A | ||||
| JP2178284A |
Foreign References:
| WO1993017022A1 | ||||
| WO1988008844A1 |
Attorney, Agent or Firm:
Ichiro Sugawara
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