Title:
トランス-縮合3,3a,8,12b-テトラヒドロ-2H-ジベンゾ[3,4:6,7]シクロヘプタ[1,2-b]フラン誘導体の製造法
Document Type and Number:
Japanese Patent JP4516752
Kind Code:
B2
Abstract:
The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
Inventors:
Lang, Jorland Lydia
Medell, Baltic Petrus Anna Maria Joseph
Hoornert, Giorzyu, Joseph Cornelius
Broset, Teeri
Francon Joseph Cornelius, Compelnor
Guillaume, Michelle Joseph Maurice Andre
Mao, Hua
Kozureki, Thomas
Medell, Baltic Petrus Anna Maria Joseph
Hoornert, Giorzyu, Joseph Cornelius
Broset, Teeri
Francon Joseph Cornelius, Compelnor
Guillaume, Michelle Joseph Maurice Andre
Mao, Hua
Kozureki, Thomas
Application Number:
JP2003549337A
Publication Date:
August 04, 2010
Filing Date:
December 02, 2002
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D307/93; A61K31/34; A61K31/343; A61P25/06; A61P25/22; A61P25/24; A61P25/28; A61P25/30
Domestic Patent References:
| JP2001519425A | ||||
| JP2005508988A |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office