Title:
酸性官能基のアルキル化方法
Document Type and Number:
Japanese Patent JP7236598
Kind Code:
B2
Abstract:
The present invention provides a method for producing a compound having an alkylated acidic functional group, the method comprising reacting, in a mixture containing two or more compounds having an acidic functional group as substrates, the compounds with an alkylating agent selected from compounds represented by formula A, formula B, or formula C in the presence of a base to alkylate the acidic functional group.
Inventors:
Tadakatsu Hayase
Satoshi Tsuchiya
Kenichi Nomura
Mount Emura
Satoshi Tsuchiya
Kenichi Nomura
Mount Emura
Application Number:
JP2022548060A
Publication Date:
March 09, 2023
Filing Date:
January 06, 2022
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07C41/16; C07C41/38; C07C43/205; C07C67/11; C07C69/76; C07C231/12; C07C231/24; C07C235/42; C07D213/65; C07D213/74; C07D213/80; C07D213/82; C07D215/54; C07D237/24; C07D239/32; C07D239/42; C07D295/155; C07D295/192; C07D295/205; C07D333/40; C07D401/12; C07D401/14; C07D409/14
Domestic Patent References:
| JP2005536492A | ||||
| JP2002308812A |
Foreign References:
| WO2006003902A1 |
Other References:
HONG,X. et al,Monofluoromethyl-Substituted Sulfonium Ylides: Preparation, Structure-Reactivity Study and Substrate,Chinese Journal of Chemistry,2020年,Vol.38, No.11,p.1317-1331
REGUEIRO-REN,A. et al,Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-,Bioorganic & Medicinal Chemistry Letters,2004年,Vol.14, No.1,p.171-175
REKHA,V.V. et al,A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carb,Organic Process Research & Development,2009年,Vol.13, No.4,p.769-773
KIM IN-HAE et al,Journal of Medicinal Chemistry,2011年,54,1752-1761
KONDO Y et al,有機超強塩基を用いる有機合成反応,有機合成化学協会誌,2005年,Vol.63, No.5,453-463
REGUEIRO-REN,A. et al,Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-,Bioorganic & Medicinal Chemistry Letters,2004年,Vol.14, No.1,p.171-175
REKHA,V.V. et al,A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carb,Organic Process Research & Development,2009年,Vol.13, No.4,p.769-773
KIM IN-HAE et al,Journal of Medicinal Chemistry,2011年,54,1752-1761
KONDO Y et al,有機超強塩基を用いる有機合成反応,有機合成化学協会誌,2005年,Vol.63, No.5,453-463
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Takuji Terachi
Toru Miyamae
Junichi Matsuo
Takuji Terachi
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