Title:
METHOD FOR AMINATING SACCHARIDE
Document Type and Number:
Japanese Patent JP3408271
Kind Code:
B2
Abstract:
PURPOSE: To obtain an aminated saccharide derivative useful for synthesizing a reduced end labeled saccharide and an artificial complex glucide by reducing a 2-aminopyridine derivative saccharide and decomposing the resultant compound under an alkali condition.
CONSTITUTION: A compound of the formula (R-CH2 is group derived from a saccharide of the formula R-CHO containing reduced end made into an aldehyde; R1 to R4 are H or lower alkyl) is reduced by using a catalyst such as palladium black at normal temperature to 100°C and then decomposed in the presence of hydrazine at room temperature to 100°C to give an aminated saccharide derivative of the formula R-CH2-NH2. A reduced end labeled saccharide obtained by reacting a saccharide containing an amino group at the reduced end, namely an aminated saccharide derivative with a labeled compound capable of reacting an amino group is useful for studying a receptor of a saccharide of organism tissue and studying lectin saccharide. An artificial complex glucide synthesizes neoglycoprotein, neoglycolipid, etc., and is useful as a medicine, an immune source, a studying reagent, etc.
Inventors:
Sumihiro Hase
Application Number:
JP21229192A
Publication Date:
May 19, 2003
Filing Date:
July 17, 1992
Export Citation:
Assignee:
Seikagaku Corporation
International Classes:
C07H15/04; C07B43/04; C07C213/02; C07C215/10; C07D213/74; C07F9/10; C07K1/107; C07K1/113; C07K2/00; C07K14/00; (IPC1-7): C07C213/02; C07C215/10; C07F9/10; C07K1/107; C07K2/00
Domestic Patent References:
| JP6410177A |
Other References:
Ａｇｒｉｃ．Ｂｉｏｌ．Ｃｈｅｍ．，１９９０，Ｖｏｌ．５４，Ｎｏ．８，Ｐ２１６９−２１７０
Ｊ．Ｂｉｏｃｈｅｍ．，１９９２，Ｖｏｌ．１１２，Ｐ２６６−２６８
Ｊ．Ｂｉｏｃｈｅｍ．，１９９２，Ｖｏｌ．１１２，Ｐ２６６−２６８
Attorney, Agent or Firm:
Tadashi Hagino (3 outside)
Previous Patent: IMAGE SEPARATING AGENT FOR THREE-DIMENSIONAL IMAGE FORMING
Next Patent: ULTRASONIC DIAGNOSTIC DEVICE
Next Patent: ULTRASONIC DIAGNOSTIC DEVICE