METHOD FOR ASSIGNING TARGET-ENRICHED SEQUENCE READS TO GENOMIC LOCATION

Japanese Patent JP2016103999

A

PROBLEM TO BE SOLVED: To provide a computer-implemented method for assigning a target-enriched sequence read to a genomic location.SOLUTION: A computer-implemented method for assigning a sequence read to a genomic location includes: a) accessing a file containing a sequence read, where the sequence read is obtained from a nucleic acid sample that has been enriched by hybridization to a plurality of capture sequences; and b) assigning the sequence read to a genomic location by: i) identifying a capture sequence as being a match with the sequence read if the sequence read contains one or more subsequences of the capture sequence; ii) calculating, using a computer, a score indicating the degree of sequence similarity between each of the matched capture sequences and the sequence read; and iii) assigning the sequence read to the genomic location if the calculated score for a matched capture sequence is above a threshold.SELECTED DRAWING: None

WO/2001/036676	SECURITY SYSTEM
WO/2004/070060	NUCLEIC ACID PROBES FOR THE DETECTION OF SMALL EXONS AND METHODS OF DESIGNING THE SAME
WO/2009/126894	METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF ANGIOGENIC DISORDERS

CHRISTIAN A LE COCQ
MAGNUS ISAKSSON
ASHUTOSH LNU
LINUS FORSMARK

JP2015215807A

June 09, 2016

November 02, 2015

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AGILENT TECHNOLOGIES INC

C12Q1/68; G16B30/00; G06F17/30; G16B30/10

Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Ayako Nakamura
Satoshi Morimoto
Yu Tanaka
Tokumoto Koichi
Mai Kodama
Akiko Mizushima

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