Title:
METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN AND USE THEREOF FOR INHIBITING NON-SMALL CELL LUNG CANCER
Document Type and Number:
Japanese Patent JP2016020372
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide chemotherapeutics for treating non-small cell lung cancer cells and use of the compositions.SOLUTION: The present invention provides a composition comprising antrocin, represented by the following formula, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. According to a method of the present invention, the composition activates caspase-3 enzyme path and inhibits the expression of XIAP, NF-kB and cyclin D1 to thus inhibit the growth of a non-small cell lung cancer cell.SELECTED DRAWING: None
Inventors:
YANG ZHEN
TZENG YEW-MIN
LI CHUANGCHUANG
LUO TUOPING
SHI HANG
YEH CHITAI
TZENG YEW-MIN
LI CHUANGCHUANG
LUO TUOPING
SHI HANG
YEH CHITAI
Application Number:
JP2015171849A
Publication Date:
February 04, 2016
Filing Date:
September 01, 2015
Export Citation:
Assignee:
YANG ZHEN
TZENG YEW-MIN
KAIYEW INVEST CORP
JENISA BIOTECHNOLOGY CORP
TZENG YEW-MIN
KAIYEW INVEST CORP
JENISA BIOTECHNOLOGY CORP
International Classes:
A61K31/343; A61P11/00; A61P35/00; A61P43/00
Other References:
JPN7016001875; ＧＥＥＴＨＡＮＧＩＬＩ， Ｍａｄａｍａｎｃｈｉ ｅｔ ａｌ．: 'Ｒｅｖｉｅｗ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｉｃａｌ Ｅｆｆｅｃｔｓ ｏｆ Ａｎｔｒｏｄｉａ ｃａｍｐｈｏｒａｔａ ａｎｄ Ｉｔｓ Ｂｉｏａｃｔｉｖｅ Ｃｏｍｐｏｕｎｄｓ' Ｅｖｉｄｅｎｃｅ-Ｂａｓｅｄ Ｃｏｍｐｌｅｍｅｎｔａｒｙ ａｎｄ Ａｌｔｅｒｎａｔｉｖｅ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．２０１１， Ａｒｔｉｃｌｅ ＩＤ ２１２６４１, 20110103, ｐ．１-１７
JPN6015021207; ＲＡＯ， Ｙ．Ｋ． ｅｔ ａｌ: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ Ａｎｔｒｏｃｉｎ ｆｒｏｍ Ａｎｔｒｏｄｉａ ｃａｍｐｈｏｒａｔａ ａｓ ａ Ｓｅｌｅｃｔｉｖｅ ａｎｄ Ｎｏｖｅｌ Ｃｌａｓｓ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ' Ｃｈｅｍｉｃａｌ Ｒｅｓｅａｒｃｈ ｉｎ Ｔｏｘｉｃｏｌｏｇｙ Ｖｏｌ．２４， Ｎｏ．２, 2011, ｐ．２３８-２４５
JPN7016001874; ＣＨＩＯＵ， Ｊｅｎｇ-Ｆｅｎｇ ｅｔ ａｌ．: 'Ａ Ｐｒｅｃｌｉｎｉｃａｌ Ｅｖａｌｕａｔｉｏｎ ｏｆ Ａｎｔｒｏｄｉａ ｃａｍｐｈｏｒａｔａ Ａｌｃｏｈｏｌ Ｅｘｔｒａｃｔｓ ｉｎ ｔｈｅ Ｔｒｅａｔｍｅｎｔ ｏｆ Ｎｏｎ-Ｓｍａｌｌ Ｌｕｎｇ' Ｅｖｉｄｅｎｃｅ-Ｂａｓｅｄ Ｃｏｍｐｌｅｍｅｎｔａｒｙ ａｎｄ Ａｌｔｅｒｎａｔｉｖｅ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．２０１１， Ａｒｔｉｃｌｅ ＩＤ ９１４５６１, 20110313, ｐ．１-１２
JPN6015021207; ＲＡＯ， Ｙ．Ｋ． ｅｔ ａｌ: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ Ａｎｔｒｏｃｉｎ ｆｒｏｍ Ａｎｔｒｏｄｉａ ｃａｍｐｈｏｒａｔａ ａｓ ａ Ｓｅｌｅｃｔｉｖｅ ａｎｄ Ｎｏｖｅｌ Ｃｌａｓｓ ｏｆ Ｓｍａｌｌ Ｍｏｌｅｃｕｌｅ' Ｃｈｅｍｉｃａｌ Ｒｅｓｅａｒｃｈ ｉｎ Ｔｏｘｉｃｏｌｏｇｙ Ｖｏｌ．２４， Ｎｏ．２, 2011, ｐ．２３８-２４５
JPN7016001874; ＣＨＩＯＵ， Ｊｅｎｇ-Ｆｅｎｇ ｅｔ ａｌ．: 'Ａ Ｐｒｅｃｌｉｎｉｃａｌ Ｅｖａｌｕａｔｉｏｎ ｏｆ Ａｎｔｒｏｄｉａ ｃａｍｐｈｏｒａｔａ Ａｌｃｏｈｏｌ Ｅｘｔｒａｃｔｓ ｉｎ ｔｈｅ Ｔｒｅａｔｍｅｎｔ ｏｆ Ｎｏｎ-Ｓｍａｌｌ Ｌｕｎｇ' Ｅｖｉｄｅｎｃｅ-Ｂａｓｅｄ Ｃｏｍｐｌｅｍｅｎｔａｒｙ ａｎｄ Ａｌｔｅｒｎａｔｉｖｅ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．２０１１， Ａｒｔｉｃｌｅ ＩＤ ９１４５６１, 20110313, ｐ．１-１２
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Shinya Mitsuhiro
Previous Patent: STABILIZED FORMULATIONS CONTAINING ANTI-INTERLEUKIN-6 RECEPTOR (IL-6R) ANTIBODIES
Next Patent: CLAY COMPOSITIONS
Next Patent: CLAY COMPOSITIONS