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Patent Searching and Data


Title:
METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN AND USE THEREOF FOR INHIBITING NON-SMALL CELL LUNG CANCER
Document Type and Number:
Japanese Patent JP2016020372
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide chemotherapeutics for treating non-small cell lung cancer cells and use of the compositions.SOLUTION: The present invention provides a composition comprising antrocin, represented by the following formula, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. According to a method of the present invention, the composition activates caspase-3 enzyme path and inhibits the expression of XIAP, NF-kB and cyclin D1 to thus inhibit the growth of a non-small cell lung cancer cell.SELECTED DRAWING: None

Inventors:
YANG ZHEN
TZENG YEW-MIN
LI CHUANGCHUANG
LUO TUOPING
SHI HANG
YEH CHITAI
Application Number:
JP2015171849A
Publication Date:
February 04, 2016
Filing Date:
September 01, 2015
Export Citation:
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Assignee:
YANG ZHEN
TZENG YEW-MIN
KAIYEW INVEST CORP
JENISA BIOTECHNOLOGY CORP
International Classes:
A61K31/343; A61P11/00; A61P35/00; A61P43/00
Other References:
JPN7016001875; GEETHANGILI, Madamanchi et al.: 'Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds' Evidence-Based Complementary and Alternative Medicine Vol.2011, Article ID 212641, 20110103, p.1-17
JPN6015021207; RAO, Y.K. et al: 'Identification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule' Chemical Research in Toxicology Vol.24, No.2, 2011, p.238-245
JPN7016001874; CHIOU, Jeng-Feng et al.: 'A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Lung' Evidence-Based Complementary and Alternative Medicine Vol.2011, Article ID 914561, 20110313, p.1-12
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro