METHOD AND COMPOSITION FOR ADJUSTING APOPTOSIS

Japanese Patent JP2010233569

A

To provide a composition and method for adjusting apoptosis by adjusting the activity of an endoplasmic reticulum transmembrane glucose regulatory protein 78 (GRP78).

This method for bringing the GRP in contact with a medicine for regulating the interaction of a cellular sol component mediating the apoptosis with the glucose regulating protein (GRP) is provided. The method for localizing the GRP at the endoplasmic reticulum, the method in which the GRP is a GRP94 or GRP78 and the method in which the cellular sol component for mediating the apoptosis is a caspase are also provided.

JP4186004	Novel N-acetylgalactosamine transferase and nucleic acid encoding it
JPH0829091	INDUSTRIAL APPLICABILITY A method for producing a hybrid PMA sequence and a vector used in the method.
WO/2001/057079	C1 INHIBITOR PRODUCED IN THE MILK OF TRANSGENIC MAMMALS

LEE AMY S

JP2010094359A

October 21, 2010

April 15, 2010

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UNIV SOUTHERN CALIFORNIA

C12N15/09; A61K31/7088; A61K38/00; A61K38/16; A61K45/00; A61K48/00; A61P9/10; A61P25/28; A61P35/00; A61P43/00; C07K14/47; C12N5/10; C12N15/113; C12Q1/02; G01N33/15; G01N33/50

WO1988003558A1	1988-05-19
US5196523A	1993-03-23

JPN6012037934; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２７４，　Ｎｏ．４０, 1999, ｐ．２８４７６-２８４８３
JPN6012037936; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．１８，　Ｎｏ．４, 200308, ｐ．８２９-８４０
JPN6012037930; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２７８，　Ｎｏ．２３, 200306, ｐ．２０９１５-２０９２４
JPN6012037932; Ｔｒｅｎｄｓ　ｉｎ　Ｂｉｏｃｈｅｍｉｃａｌ　Ｓｃｉｅｎｃｅｓ Ｖｏｌ．２６，　Ｎｏ．８, 2001, ｐ．５０４-５１０

Yuichi Yamada
Masakazu Noda
Ikeda adult
Kinno Watanabe

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