To provide a therapeutic protein, polypeptide (e.g. interferon and intron A) or gene delivery system to an epithelial cell, especially urothelial cell, or a method for improving the delivery of a nucleic acid.
A protein or a nucleic acid encoding the protein is administered to a target tissue or organ by being combined with a therapy using a delivery-enhancing factor for enhancing the delivery of the interferon or the nucleic acid to the cells of the target tissue or organ. The method and the combination are effective for the therapy of a cancer or other conditions responsive to interferon therapy. An exemplary method comprises the transurethral intravesical administration to the bladder of a therapeutically effective amount of a pharmaceutical composition comprising α-interferon and a delivery system of the gene encoding the interferon, and SYN3 or a SYN3 homolog or analog.
COPYRIGHT: (C)2008,JPO&INPIT
NAGABHUSHAN TATTANAHALLI L
YOUNGSTER STEPHEN
CONNOR ROBERT
| WO1999002191A1 | 1999-01-21 |
Takaaki Yasumura
Natsuki Morishita