To provide a new chimeric adenovirus vector, to provide a method for efficiently creating the same, and to provide pharmaceuticals to which the new chimeric adenovirus vector is applied.
The new chimeric adenovirus is created from a vector DNA with the fiber knob region of type 35 adenovirus integrated in type 5 adenovirus and a second vector DNA where the expression of E1A and E1B genes of the type 5 adenovirus is made controllable by an extraneous transcriptional control region. This chimeric adenovirus, which a modified type 5 adenovirus, is such that its fiber knob region is substituted by the fiber knob region of the type 35 adenovirus and the E1A transcriptional control region is eliminated, and at the resulting site, an arbitrary extraneous transcriptional control region controlling the expression of the E1A and E1B genes is introduced. This chimeric adenovirus is capable of melting cells or tumors, thus being applicable, for example, to pharmaceuticals having high cell-damaging activity against intractable tumors.
KAWAMURA KIYOKO
TAKENOBU NAONORI
ARISTO KK
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