To provide a cryopreserving agent for cryopreserving bone marrow cells, cord blood cells or peripheral stem cells without degradation and an activity-maintaining agent for bone marrow cells, cord blood cells or peripheral stem cells for keeping activity of the bone marrow cells, the cord blood cells or the peripheral blood stem cells and enhancing transplantation efficiency at the time of transplantation.
The cryopreserving agent for bone marrow cells, cord blood cells or peripheral blood stem cells, or the activity maintaining agent for bone marrow cells, cord blood cells or peripheral blood stem cells contains an FNK protein having at least one substitution among the substitution of Try at the 22th position of Bcl-xL protein to Phe, the substitution of Gln at the 26th position to Asn and the substitution of Arg at the 165 position to Lys as an effective component.
ASO SADAMITSU
TAIRA SHUHEI
JPN6010061457, Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ．， ｖｏｌ．９９（２６）， ｐｐ．１７１０７−１７１１２ （２００２）
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka