Title:
METHOD FOR DECREASING EXPRESSION OF CD36
Document Type and Number:
Japanese Patent JP2013075915
Kind Code:
A
Abstract:
To provide a method for decreasing an expression of CD36 by a cell.
The method includes a step of placing the cell in contact with an effective amount of the aromaticity cation peptide having the following behaviors: at least one net positive charge; four amino acids at a minimum; about twenty amino acids at a maximum; a relation that 3p m is a maximum number of r+1 or less between a minimum number (p m) of net positive charge and a total amino acid residue (r); and a relation that 2a is a maximum number of pt+1 or less between a minimum number (a) of aromatic group and a total net positive charge (p t), but when a is 1, p t can also be1.
Inventors:
SZETO HAZEL H
LIU SHAOYI
CHO SUNGHEE
LIU SHAOYI
CHO SUNGHEE
Application Number:
JP2013006199A
Publication Date:
April 25, 2013
Filing Date:
January 17, 2013
Export Citation:
Assignee:
CORNELL RES FOUNDATION INC
International Classes:
A61K38/00; A61K38/08; A61P3/10; C07K5/10
Domestic Patent References:
| JPH10158260A | 1998-06-16 | |||
| JP4931604B2 | 2012-05-16 | |||
| JP2004511526A | 2004-04-15 | |||
| JP2008531412A | 2008-08-14 |
Foreign References:
| WO2005072295A2 | 2005-08-11 | |||
| WO2004070054A2 | 2004-08-19 | |||
| WO2005055706A1 | 2005-06-23 | |||
| WO2004075856A2 | 2004-09-10 |
Other References:
ZHAO,K. ET AL, CELL-PERMEABLE PEPTIDE ANTIOXIDANTS TARGETED TO INNER MITOCHONDRIAL MEMBRANE INHIBIT, JPN6012008470, ISSN: 0002772179
MORIYAMA, T ET AL, 日本腎臓学会誌, 2000, VOL.42, NO.3, P.142, JPN6012008471, ISSN: 0002772180
NAKATANI, T ET AL, JPN J PHARMACOL, 2002, VOL.90, NO.4, P.361-4, JPN6012008472, ISSN: 0002772181
IMADA, T ET AL, J PHARMACOL SCI, 2005 MAR, VOL.97, SUPPL. 1, P.97P, JPN6012008473, ISSN: 0002772182
MORIYAMA, T ET AL, 日本腎臓学会誌, 2000, VOL.42, NO.3, P.142, JPN6012008471, ISSN: 0002772180
NAKATANI, T ET AL, JPN J PHARMACOL, 2002, VOL.90, NO.4, P.361-4, JPN6012008472, ISSN: 0002772181
IMADA, T ET AL, J PHARMACOL SCI, 2005 MAR, VOL.97, SUPPL. 1, P.97P, JPN6012008473, ISSN: 0002772182
Attorney, Agent or Firm:
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Toshio Takizawa
Atsushi Hakoda
Kenji Asai
Toshio Takizawa
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