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Title:
METHOD FOR DEPOLYMERIZING HEPARIN, DEPOLYMERIZED HEPARIN, DERIVATIVE THEREOF AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JP2001240607
Kind Code:
A
Abstract:

To provide a method for depolymerizing a heparin, to obtain a new depolymerized heparin prepared by the method for depolymerization and its amidated derivative and further a pharmaceutical composition comprising the depolymerized heparin and its amidated derivative as active ingredients.

This method for depolymerizing the heparin is characterized by using a reducing metal and a metal oxide and the method for depolymerizing the heparin comprises the step. The depolymerized heparin is obtained by the method for depolymerization. Furthermore, the amidated depolymerized heparin is obtained and an anticoagulant, a therapeutic agent for renal diseases, a platelet aggregation inhibitor, a radical scavenger, a mesangium cell proliferation inhibitor and a complement activity inhibitor comprise the depolymerized heparin or the amidated depolymerized heparin derivative.


Inventors:
ARAKI HIROMASA
KAWAI KENZO
TANAKA SHUICHI
NISHIMURA KOUYO
OTANI HIRONARI
NISHIKAWA HIROYUKI
TAKEDA SEIICHI
SHIMADA CHIAKI
KITAGAWA CHIZUKO
ABE TOMOYUKI
Application Number:
JP2000053475A
Publication Date:
September 04, 2001
Filing Date:
February 29, 2000
Export Citation:
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Assignee:
FUSO PHARMACEUTICAL IND
International Classes:
A61K31/727; A61P7/02; A61P13/12; A61P39/06; C08B37/10; (IPC1-7): C08B37/10; A61K31/727; A61P7/02; A61P13/12; A61P39/06
Domestic Patent References:
JPH09286803A1997-11-04
JPS63500184A1988-01-21
JPH11130801A1999-05-18
JPS59187002A1984-10-24
JPH0231081B21990-07-11
JP4042401B
JPH0231721B21990-07-16
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)



 
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