Title:
体液中のアミロイド-βオリゴマーの検出方法
Document Type and Number:
Japanese Patent JP5009987
Kind Code:
B2
Abstract:
The present invention relates to a method for the detection of marker of the Alzheimer's disease, namely the amyloid-² oligomers in human CSF, using a combination of steps including demasking the epitopes responsible for antibody binding on the A² peptide oligomers as well as detecting fluorescently marked antibodies binding to said epitopes, preferably by using the FRET technology.
Inventors:
Navarrete Santos Alexander
Bowem Gerald
Bowem Gerald
Application Number:
JP2009521170A
Publication Date:
August 29, 2012
Filing Date:
July 27, 2007
Export Citation:
Assignee:
Vista Ventures Game Behr
International Classes:
G01N33/542; G01N21/78; G01N33/53; G01N33/531; C07K14/47
Domestic Patent References:
| JP2003513294A | ||||
| JP2001517800A | ||||
| JP2007524574A |
Other References:
BACSKAI BRIAN J,JOURNAL OF BIOMEDICAL OPTICS,2003年 7月,V8 N3,P368-375
Garzon-Rodriguez W et al,Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations,J Biol Chem,1997年 8月22日,272(34),21037-21044
Garzon-Rodriguez W et al,Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations,J Biol Chem,1997年 8月22日,272(34),21037-21044
Attorney, Agent or Firm:
Kazuhiro Kiyohara