METHOD FOR DETECTION, IDENTIFICATION, ISOLATION, AND SELECTIVE LABELING AND TARGETING OF TH1 LYMPHOCYTE WITH LAG-3 PROTEIN

Title:

METHOD FOR DETECTION, IDENTIFICATION, ISOLATION, AND SELECTIVE LABELING AND TARGETING OF TH1 LYMPHOCYTE WITH LAG-3 PROTEIN

Document Type and Number:

Japanese Patent JP2008150362

Kind Code:

A

Abstract:

To provide a method for detection, identification, isolation, and selective labeling and targeting of TH1 lymphocyte, and a therapeutic method of infectious diseases, cancers, Th1 mediated diseases, and diseases associated with the imbalance of Th1 and Th2 cells.

The lymphocyte activating gene (LAG-3) is a member of immunoglobulin super family selectively transcripted in human activated T and NK cells. LAG-3 on the surface of Th1 lymphocyte is used as a marker and can detect and identify Th1 lymphocyte, and discriminate from Th2 lymphocyte. A monoclonal antibody to LAG-3 is used for detection and isolation of Th1 cells and diagnosis of Th1 mediated diseases, and for the treatment of infectious diseases, cancers and diseases associated with Th1/Th2 imbalance.

Inventors:

ROMAGNANI SERGIO (IT)

Application Number:

JP2007289509A

Publication Date:

July 03, 2008

Filing Date:

November 07, 2007

Export Citation:

Click for automatic bibliography generation Help

Assignee:

APPLIED RESEARCH SYSTEMS (AN)
INST NAT SANTE RECH MED
ROUSSY INST GUSTAVE

International Classes:

A61K35/14; C12N15/09; A01N1/02; A01N63/00; A61K31/00; A61K35/26; A61K35/66; A61K38/00; A61K39/395; A61K45/00; A61P31/00; A61P35/00; A61P37/00; A61P37/04; A61P43/00; B01D15/08; B01D43/00; B01D57/00; B03C1/00; C07K14/705; C07K16/00; C07K16/28; C12N5/00; C12N5/0783; C12N15/02; C12P21/08; G01N33/48; G01N33/53; G01N33/536; G01N33/543; G01N33/553; G01N33/569; A61K39/00; C07K14/47; C07K16/18

Attorney, Agent or Firm:

Junji Kamata
Toshio Shiozawa
Masazumi Imamura

Previous Patent: METHOD FOR PREPARATION OF PYRIDINE-METHYLSULFINYL COMPOUND

Next Patent: CYCLOPROPENE COMPOSITION