Title:
METHOD FOR DIASTEREOSELECTIVELY SYNTHESIZING NUCLEOSIDE
Document Type and Number:
Japanese Patent JP3229013
Kind Code:
B2
Abstract:
PURPOSE: To obtain optically active cis-nucleoside and a compd. analogous to the nucleoside by glycosylating purine or pyrimidine bases with a specified intermediate in the presence of a specified Lewis acid.
CONSTITUTION: Desired purine or pyrimidine bases are glycosylated with an intermediate of formula I or II (wherein R3 is substd. carbonyl, etc.; L is a leaving group; and W and X are each S, S=O, SO2 or O) in the presence of a Lewis acid of formula II [wherein R5-R7 are each H, 1-20C alkyl, substd. aralkyl, 6-20C aryl, etc., and R8 is halogen, (halogen substd.) 1-20C sulfonic ester, etc.] to obtain the objective compds. of formula IV (wherein R1 is H or acyl and R2 is a purine or pyrimidine base).
Inventors:
Tarekman Sur
Haorn Jin
Alan H. L. Tse
M. Arshad Sidiki
Haorn Jin
Alan H. L. Tse
M. Arshad Sidiki
Application Number:
JP12915592A
Publication Date:
November 12, 2001
Filing Date:
May 21, 1992
Export Citation:
Assignee:
Biochem Pharma Inc.
International Classes:
A61K31/513; A61P31/12; B01J31/02; C07B53/00; C07B61/00; C07C13/10; C07D207/00; C07D231/04; C07D233/02; C07D261/02; C07D263/04; C07D275/02; C07H19/00; C07D277/04; C07D285/04; C07D291/04; C07D307/04; C07D307/16; C07D307/18; C07D307/24; C07D317/08; C07D317/24; C07D317/32; C07D317/34; C07D323/02; C07D327/04; C07D333/48; C07D339/02; C07D339/06; C07D341/00; C07D403/04; C07D405/04; C07D407/04; C07D409/04; C07D411/04; C07D411/12; C07D411/14; C07D413/04; C07D419/04; C07D471/00; C07D473/00; C07D473/06; C07D473/30; C07D473/34; C07H19/04; C07H19/06; C07H19/16; C07D; (IPC1-7): C07D411/04; B01J31/02; C07B53/00; C07D317/32; C07D327/04; C07D339/06; C07D405/04; C07D473/06; C07D473/30; C07D473/34
Domestic Patent References:
| JP51146342A |
Other References:
【文献】米国特許4182718(US,A)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)