Title:
METHOD FOR EXAMINING BONE-JOINT DISEASE BASED ON SINGLE NUCLEOTIDE POLYMORPHISM OF HLA GENE LOCUS AND LONG ARM 25.1 REGION OF CHROMOSOME 15
Document Type and Number:
Japanese Patent JP2011010607
Kind Code:
A
Abstract:
To provide a method for examining bone-joint diseases such as osteoarthritis, etc.
Onset of osteoarthritis is associated with single nucleotide polymorphisms (SNP) existing in HLA gene locus and long arm 25.1 region of chromosome 15 and the polymorphisms are examined to accurately estimate onset risk and onset of bone-joint diseases such as osteoarthritis, etc. A probe for examining bone-joint diseases has a specific sequence of ≥10 bases or its complementary sequence. A primer for examining bone-joint diseases amplifies a region containing a base of specific base number in a specific sequence.
Inventors:
IKEGAWA SHIRO
NAKAJIMA MASAHIRO
NAKAJIMA MASAHIRO
Application Number:
JP2009158205A
Publication Date:
January 20, 2011
Filing Date:
July 02, 2009
Export Citation:
Assignee:
INST PHYSICAL & CHEMICAL RES
International Classes:
C12N15/09; C12Q1/68
Other References:
JPN6013056074; 医学のあゆみ， （２００８）， ２２５， ［９］， ｐ．８０６-８１０
JPN6013056076; 医学のあゆみ， （２００８）， ２２７， ［８］， ｐ．６２５-６２６
JPN6013056076; 医学のあゆみ， （２００８）， ２２７， ［８］， ｐ．６２５-６２６
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Mayuko Wakuda
Tsutomu Toyama
Shinichi Sanuki
Hidemi Matsukura
Mayuko Wakuda
Tsutomu Toyama
Shinichi Sanuki