Title:
METHOD FOR IMPROVING LUBRICATION OF JOINT BY NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST
Document Type and Number:
Japanese Patent JP2003176240
Kind Code:
A
Abstract:
To provide a method for altering the amount or composition of the synovial fluid secreted from the joint of a patient to be treated.
The purpose can be achieved by administering to a patient with a nicotinic receptor agonist such as nicotine, transmetanicotine, epibatidine and lobeline, imidacloprid which is an analog of such nicotinic receptor agonists, pyridol or a p-alkylthiophenol derivative in an amount effective to stimulate the synovial secretion. Pharmaceutical formulations and methods of making the same are also disclosed. The invention is useful for treatment of diseases relating to the sclerosis of the joint such as osteoarthritis after the arthroplastic operation.
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Inventors:
YERXA BENJAMIN R
COWLEN MATTHEW S
COWLEN MATTHEW S
Application Number:
JP2002297055A
Publication Date:
June 24, 2003
Filing Date:
October 10, 2002
Export Citation:
Assignee:
INSPIRE PHARMACEUTICALS INC
International Classes:
C07D487/08; A61K9/02; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K9/12; A61K9/20; A61K9/68; A61K9/70; A61K31/00; A61K31/40; A61K31/4168; A61K31/4178; A61K31/42; A61K31/422; A61K31/4406; A61K31/4427; A61K31/4439; A61K31/444; A61K31/445; A61K31/465; A61K31/501; A61K31/504; A61K45/00; A61P19/02; A61P43/00; C07D207/08; C07D211/22; C07D213/38; C07D401/04; C07D401/06; C07D413/04; C07D471/08; (IPC1-7): A61K45/00; A61K9/02; A61K9/06; A61K9/08; A61K9/10; A61K9/107; A61K9/12; A61K9/20; A61K9/68; A61K9/70; A61K31/40; A61K31/42; A61K31/4406; A61K31/4439; A61K31/444; A61K31/445; A61K31/501; A61P19/02; A61P43/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)