Title:
２−ヒドロキシカルボン酸又はその誘導体の光学純度向上法
Document Type and Number:
Japanese Patent JP5734533
Kind Code:
B2
Abstract:
To provide a method for improving optical purity of an optically active 2-hydroxycarboxylic acid or a derivative thereof, which is useful as a raw material in the manufacture of medicines, agrochemicals, and industrial products. The method of the invention for improving purity of a hydroxycarboxylic acid of the following formula (1a) or (1b) or a derivative thereof includes the steps of reacting the hydroxycarboxylic acid of the following formula (1a) or (1b) with at least one optically inactive base selected from the group consisting of an alkali metal alkoxide and a secondary amine in the presence of a solvent and, subsequently, performing recrystallization, to thereby form a hydroxycarboxylic acid salt of the following formula (IIIa) or (IIIb):
,wherein R 1 represents a C 1-8 alkyl group, and R 2 represents an alkali metal or a secondary amine.
Inventors:
Yuko Yamazaki
Application Number:
JP2014561674A
Publication Date:
June 17, 2015
Filing Date:
March 28, 2014
Export Citation:
Assignee:
Kowa Co., Ltd.
International Classes:
C07C51/487; C07B57/00; C07C51/43; C07C51/50; C07C59/01; C07C67/08; C07C69/675; C07D263/58
Domestic Patent References:
| JPH01175956A | 1989-07-12 |
Foreign References:
| WO2007013555A1 | 2007-02-01 | |||
| WO2005023777A1 | 2005-03-17 |
Other References:
JPN6014026956; ＭＡＳＡＡＫＩ ＮＡＫＡＨＡＴＡ， ｅｔ ａｌ．: 'Ｔｈｅ Ｐｒｅｐａｒａｔｉｏｎ ｏｆ Ｏｐｔｉｃａｌｌｙ Ｐｕｒｅ ３-Ｈｙｄｒｏｘｙａｌｋａｎｏｉｃ Ａｃｉｄ． Ｔｈｅ Ｅｎａｎｔｉｏｆａｃｅ-ｄｉｆｆｅｒｅｎｔｉａｔｉｎｇ Ｈｙｄｒｏｇｅｎａｔ' Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ Ｖｏｌ．５５， Ｎｏ．７, 1982, ｐｐ．２１８６-２１８９
JPN6014026957; ＴＡＤＡＳＨＩ ＫＩＫＵＫＡＷＡ， ｅｔ ａｌ．: 'Ｔｈｅ ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｏｐｔｉｃａｌｌｙ ｐｕｒｅ ３-ｈｙｄｅｏｘｙｂｕｔａｎｏｉｃ ａｃｉｄ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅｓ ａｓ ｔｈｅ ｄｉｂｅｎｚｙｌａｍｍｏｎｉｕｍ' Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｎｏ．７, 1987, ｐｐ．１２６７-１２７０, Ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ
JPN6014026957; ＴＡＤＡＳＨＩ ＫＩＫＵＫＡＷＡ， ｅｔ ａｌ．: 'Ｔｈｅ ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｏｐｔｉｃａｌｌｙ ｐｕｒｅ ３-ｈｙｄｅｏｘｙｂｕｔａｎｏｉｃ ａｃｉｄ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅｓ ａｓ ｔｈｅ ｄｉｂｅｎｚｙｌａｍｍｏｎｉｕｍ' Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｎｏ．７, 1987, ｐｐ．１２６７-１２７０, Ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｊａｐａｎ
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto