Title:
METHOD OF MANUFACTURING PHOSPHOROAMIDE COMPOUND AND OPTICALLY ACTIVE ALCOHOL
Document Type and Number:
Japanese Patent JP2014040457
Kind Code:
A
Abstract:
To provide a method of high efficiency and high enantioselectivity for manufacturing an optically active alcohol from a carbonyl compound, and to provide a ligand used therefor.
An optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a phosphoroamide compound represented by a ligand (L) as a catalyst, where Ra is a monovalent hydrocarbon group having 3 or more carbon atoms, Rb is a different monovalent hydrocarbon group to Ra, Ra and Rb may bond to each other to form a ring, R is an alkyl group, an aryl group or the like, R1 to R5 are each independently a monovalent hydrocarbon group, R2 and R33, and R4 and R5 may bond to each other to form a ring.
Inventors:
ISHIHARA KAZUAKI
HATANO MANABU
MIYAMOTO TAKASHI
HATANO MANABU
MIYAMOTO TAKASHI
Application Number:
JP2013209580A
Publication Date:
March 06, 2014
Filing Date:
October 04, 2013
Export Citation:
Assignee:
UNIV NAGOYA
SEKISUI MEDICAL CO LTD
SEKISUI MEDICAL CO LTD
International Classes:
C07F9/572; B01J31/24; C07C29/143; C07C29/38; C07C33/14; C07C33/18; C07C33/20; C07C33/24; C07C33/34; C07C41/30; C07C43/23; C07D333/16; C07F9/36; C07F9/553; C07F9/59; C07F9/6533; C07B53/00; C07B61/00; C07F3/06
Domestic Patent References:
| JPS5395919A | 1978-08-22 |
Other References:
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Attorney, Agent or Firm:
Kiyoshi Kojima
Yoshinobu Hagino
Yoshinobu Hagino
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