Title:
酸化還元反応による血漿タンパク質の結合特異性の改変方法
Document Type and Number:
Japanese Patent JP4662557
Kind Code:
B2
Abstract:
The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.
Inventors:
McIntyre, John A
Application Number:
JP2006515229A
Publication Date:
March 30, 2011
Filing Date:
June 09, 2004
Export Citation:
Assignee:
Redox-Reactive Reagents Limited Liability Company
International Classes:
C07K1/113; A61K39/395; B01D57/02; C07K1/24; C07K1/26; C07K14/475; C07K14/765; C07K16/00; C07K16/06; C07K16/18; C12N15/01; G01N33/53; G01N33/561; G01N33/564; G01N
Domestic Patent References:
| JP2502580A | ||||
| JP2000517302A | ||||
| JP9169650A |
Foreign References:
| US5939394 |
Other References:
Eur. J. Immunol.,1998年,Vol.28,pp.2108-2114
J. Immunol. Methods,1998年,Vol.216,pp.117-137
Autoantibodies,1996年,pp.357-363
Clin. Exp. Immunol.,1993年,Vol.93,pp.265-268
J. Immunol. Methods,1998年,Vol.216,pp.117-137
Autoantibodies,1996年,pp.357-363
Clin. Exp. Immunol.,1993年,Vol.93,pp.265-268
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Seiji Tani
Yousuke Fujimori
Seiji Tani