Title:
METHOD FOR MODULATING BINDING ACTIVITY OF NOVEL ICAM-3 BINDING RECEPTOR ON SINUSOIDAL ENDOTHELIAL CELL IN LIVER AND LYMPH NODE
Document Type and Number:
Japanese Patent JP2005132846
Kind Code:
A
Abstract:
To obtain a compound binding to a C-type lectin on the surfaces of sinusoidal endothelial cells in liver and lymph nodes to modulate the immune response in animals.
The use of the compound that binds to the C-type lectin on the surface of a sinusoid endothelial layer, in the preparation of a composition for modulating, in particular reducing the immune response in animal (in particular a human or another mammal) is provided. In one embodiment, the sinusoid endothelial layer is constituted with liver sinusoid endothelial cells (LSEC) and, in another embodiment, the sinusoid endothelial layer is constituted with a lymph node sinusoidal zone.
Inventors:
FIGDOR CARL GUSTAV
GEIJTENBEEK TEUNIS BERNARD HER
KOOYK YVETTE VAN
TORENSMA RUURD
GEIJTENBEEK TEUNIS BERNARD HER
KOOYK YVETTE VAN
TORENSMA RUURD
Application Number:
JP2004368543A
Publication Date:
May 26, 2005
Filing Date:
December 20, 2004
Export Citation:
Assignee:
STICHTING KATHOLIEKE UNIV
International Classes:
A61K38/00; A61K39/00; A61K39/02; C12N15/09; A61K39/21; A61K39/395; A61K45/00; A61P31/18; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K14/705; C07K16/28; C12N5/00; C12N5/071; G01N33/53; A61K38/095; C12R1/91; (IPC1-7): A61K45/00; A61K38/00; A61P37/02
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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