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Title:
METHOD FOR MULTIPLE QUANTIFICATION OF AMINO GROUP-CONTAINING NON-PEPTIDE COMPOUND WITH HIGH EFFICIENCY AND HIGH SENSITIVITY, AND KIT THEREFOR
Document Type and Number:
Japanese Patent JP2012215556
Kind Code:
A
Abstract:

To provide a method allowing analysis of an amino group-containing non-peptide compound in a biological sample with higher sensitivity and also collective quantification of a plurality of biological samples.

A quantification method of an amino group-containing non-peptide compound comprising a step of giving mass difference to an amino group-containing non-peptide compound as an object of measurement contained in a biological sample and an internal standard sample as an object of analysis, using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): (in which, R1, R2 and R3 are each the same or different and shows hydrogen, halogen or alkyl) or a salt thereof, as a labeled compound. A kit is used to carry out the method.


Inventors:
MATSUKAWA SHIGERU
NARITA KAZUMI
SHIMOHIRA HARUKI
Application Number:
JP2012036598A
Publication Date:
November 08, 2012
Filing Date:
February 22, 2012
Export Citation:
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Assignee:
UNIV FUKUI
TAIYO NIPPON SANSO CORP
International Classes:
G01N27/62
Domestic Patent References:
JPH021430A1990-01-05
JP2007163423A2007-06-28
JP2006189277A2006-07-20
JPH021430A1990-01-05
JP2007163423A2007-06-28
Foreign References:
WO2008156139A12008-12-24
Other References:
JPN6015043773; 松川茂: '１回のＭＡＬＤＩ／ＭＳまたはＬＣ／ＭＳ分析で多試料中の神経アミンとアミノ酸の一斉定量を可能にする方法の開発' 生化学 抄録ＣＤ, 20090625, Ｐａｇｅ．ＲＯＭＢＵＮＮＯ．４Ｐ-７７３
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma



 
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