Title:
ＩＮＳＭ１の発現に基づくＬＳＤ１阻害剤の治療効果の予測方法
Document Type and Number:
Japanese Patent JP6915056
Kind Code:
B2
Abstract:
A method for predicting a therapeutic effect of a chemotherapy using an antitumor agent comprising an LSD1 inhibitor in a cancer patient based on an expression level of INSM1 in a sample containing tumor cells isolated from the cancer patient.
Inventors:
Ryo Hatanaka
Application Number:
JP2019521254A
Publication Date:
August 04, 2021
Filing Date:
May 30, 2018
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
G01N33/68; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/407; A61K31/416; A61K31/4188; A61K31/4192; A61K31/423; A61K31/427; A61K31/437; A61K31/438; A61K31/439; A61K31/445; A61K31/4468; A61K31/46; A61K31/4709; A61K31/4725; A61K31/495; A61K31/498; A61K31/4995; A61K31/502; A61K31/517; A61K31/519; A61K31/538; A61K31/5386; A61K31/55; A61K31/551; A61P35/00; A61P43/00; C07D207/14; C07D209/52; C07D211/56; C07D211/58; C07D223/12; C07D243/08; C07D295/192; C07D403/10; C07D405/10; C07D413/10; C07D417/10; C07D451/04; C07D451/14; C07D471/04; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D498/10; C07D519/00; C07K16/32; G01N33/574
Foreign References:
| WO2017013061A1 |
Other References:
Shinji Takagi,LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B,Cancer Res,2017年 9月 1日,Vol.77 No.17,Page.4652-4662,Epub 2017 Jun 30.
ROSENBAUM Jason N,INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms,American Journal of Clinical Pathology,2015年10月,Vol.144 No.4,Page.579-591
INSM1 (A-8): sc-271408,2016年10月 6日,URL,https://datasheets.scbt.com/sc-271408.pdf
Helai P Mohammad,A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC,Cancer Cell,2015年 7月13日,Vol.28 No.1,Page.57-69
Marcello Tortorici,Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase,ACS Chem Biol,2013年 8月16日,Vol.8 No.8,Page.1677-1682
ROSENBAUM Jason N,INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms,American Journal of Clinical Pathology,2015年10月,Vol.144 No.4,Page.579-591
INSM1 (A-8): sc-271408,2016年10月 6日,URL,https://datasheets.scbt.com/sc-271408.pdf
Helai P Mohammad,A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC,Cancer Cell,2015年 7月13日,Vol.28 No.1,Page.57-69
Marcello Tortorici,Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase,ACS Chem Biol,2013年 8月16日,Vol.8 No.8,Page.1677-1682
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office