Title:
S-(-)-クロロコハク酸またはその誘導体からR-(-)-カルニチンを調製するための方法
Document Type and Number:
Japanese Patent JP4584464
Kind Code:
B2
Abstract:
A process for the preparation of S-(-)-chlorosuccinic acid comprising the reaction between S-(+)-aspartic acid and sodium nitrite in a hydrochloric acid-aqueous milieu being said S-(+)-aspartic acid suspended in demineralised water in a w/v ratio ranging from 1 kg/L to 0.5 kg/L, and concentrated hydrochloric acid being added in a ratio of S-(+)-aspartic acid to hydrochloric acid ranging from 0.35 kg/L to 0.55 kg/L, in the presence of sodium chloride, said S-(+)-aspartic acid and said sodium chloride being in a molar ratio ranging from 1:0.3 to 1:0.5, the improvement wherein consists in the isolation by precipitation of the reaction product by cooling the reaction mixture at a temperature ranging from -10 DEG C to -20 DEG C.
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Inventors:
Clown meloni
Alberto Celli
Marco Santa Gostino
Alberto Celli
Marco Santa Gostino
Application Number:
JP2000618226A
Publication Date:
November 24, 2010
Filing Date:
May 12, 2000
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C07C227/08; C07B53/00; C07D307/60; C07C51/363; C07C51/377; C07C51/48; C07C51/56; C07C55/32; C07C55/40; C07C69/63; C07C227/30; C07C227/32; C07C229/22; C07C309/66
Domestic Patent References:
| JP50082015A | ||||
| JP58090560A | ||||
| JP58113157A |
Other References:
Biochemistry,Vol.27, No.6,p.2222-2228 (1988).
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Michiko Matsutani
Mitsuo Tanaka
Michiko Matsutani