Title:
細胞毒性ベンゾジアゼピン誘導体の調製方法
Document Type and Number:
Japanese Patent JP6995178
Kind Code:
B2
Abstract:
The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Inventors:
Gerard, Beaudouin
Shizuka, Manami
Miller, Michael Lewis
Silva, Richard A.
Shizuka, Manami
Miller, Michael Lewis
Silva, Richard A.
Application Number:
JP2020180147A
Publication Date:
February 21, 2022
Filing Date:
October 28, 2020
Export Citation:
Assignee:
Immunogen Incorporated
International Classes:
C07C303/24; A61K31/5517; C07C309/66; C07D487/04; C07D519/00
Domestic Patent References:
| JP2014521591A |
Other References:
KAMAL, A. et al.,Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity,Dhem. Commun.,2001年,Vol.5,pp.437-438,DOI:10.1039/b009195m
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Ichinomiya Ichinomiya
Toru Miyamae
Ichinomiya Ichinomiya