Title:
ガドリニウム系イオン性造影剤の中間体の調製方法及びその応用
Document Type and Number:
Japanese Patent JP7240397
Kind Code:
B2
Abstract:
The present invention provides a preparation method and application of an intermediate of gadolinium-based ionic contrast agent. The preparation method comprises the following step: allowing a substance represented by the general formula (II) to react a substance represented by the general formula (III) or a substance represented by the general formula (IV) in the presence of a basic catalyst to generate an intermediate of gadolinium-based ionic contrast agent containing the structure represented by the general formula (I) or the general formula (V), wherein R represents C1-C5 alkyl, benzyl or benzyl derivative, R1 represents -H or -CH2OH, and R2 represents -CH3 or -OH. When preparing an intermediate of gadolinium-based ionic contrast agent having the structure represented by the general formula (I) using the above-mentioned preparation method, it can provide the advantages of simple reaction, fewer steps, controllable reaction, a yield up to 99% or more, and a purity greater than 99.5% for the obtained product.
Inventors:
Zhang, Jihwa
Ryu, Yunlong
Ryu, Yunlong
Application Number:
JP2020529184A
Publication Date:
March 15, 2023
Filing Date:
January 29, 2019
Export Citation:
Assignee:
HUBEI TIANSHU PHARMACEUTICAL CO., LTD
International Classes:
C07D257/02; A61K49/10; C07D405/04
Domestic Patent References:
| JP2002510296A | ||||
| JP2002503238A | ||||
| JP11021279A |
Foreign References:
| WO2017178301A1 | ||||
| US20020098152 | ||||
| CN108047151A |
Other References:
PLATZEK, J. et al.,Synthesis and Structure of a New Macrocyclic Polyhydroxylated Gadolinium Chelate Used as a Contrast Agent for Magnetic Resonance Imaging,Inorganic Chemistry,1997年,36(26),pp. 6086-6093
FERRAUTO, G. et al.,Modifying LnHPDO3A Chelates for Improved T1 and CEST MRI Applications,Chemistry A European Journal,2019年,25(16),pp. 4184-4193
FERRAUTO, G. et al.,Modifying LnHPDO3A Chelates for Improved T1 and CEST MRI Applications,Chemistry A European Journal,2019年,25(16),pp. 4184-4193
Attorney, Agent or Firm:
Ryu Iwatani
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