Title:
アルコール溶媒中での有機フルオロ化合物の調製方法
Document Type and Number:
Japanese Patent JP4981683
Kind Code:
B2
Abstract:
The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
Inventors:
Moon, dehuk
Ji, Deyeon
Kim, Don Wook
Oh, Jun
Liu, Jin-souk
Ji, Deyeon
Kim, Don Wook
Oh, Jun
Liu, Jin-souk
Application Number:
JP2007546555A
Publication Date:
July 25, 2012
Filing Date:
December 09, 2005
Export Citation:
Assignee:
FUTURECHEM CO., LTD.
THE ASAN FOUNDATION
THE ASAN FOUNDATION
International Classes:
C07C17/093; C07C22/08; C07C41/22; C07C43/225; C07C213/08; C07C215/40; C07C253/30; C07C255/30; C07D207/16; C07D233/91; C07D451/02; C07H5/02; C07H19/073; C07J1/00; C07B59/00
Domestic Patent References:
| JP5301844A | ||||
| JP30000215B1 | ||||
| JP2002523383A |
Foreign References:
| US2980670 | ||||
| WO2003002157A1 | ||||
| WO1995009844A1 | ||||
| WO2002060913A1 |
Other References:
大学院 有機化学(中),株式会社 講談社,1988年 6月20日,278-279頁
Journal of Labelled Compounds and Radiopharmaceuticals,1988年,Vol.25,p.721-729
Journal of Medicinal Chemistry,1990年,Vol.33,p.3143-3155
The Journal of Nuclear Medicine,2001年,Vol.42,p.1805-1814
Journal of Labelled Compounds and Radiopharmaceuticals,1988年,Vol.25,p.721-729
Journal of Medicinal Chemistry,1990年,Vol.33,p.3143-3155
The Journal of Nuclear Medicine,2001年,Vol.42,p.1805-1814
Attorney, Agent or Firm:
Kiyoji Kuzuwa