Title:
METHOD FOR PRODUCING 3-METHYLISOQUINOLINE
Document Type and Number:
Japanese Patent JP3526608
Kind Code:
B2
Abstract:
PURPOSE: To profitably obtain 3-methylisoquinoline in an one step reaction by reacting isoquinoline with an alkanol in the presence of a metal catalyst selected from iron, nickel and cobalt, the isoquinoline and the alkanol being inexpensive raw materials.
CONSTITUTION: Isoquinoline is reacted with a 1-2C alkanol in the presence of a metal catalyst containing at least one of iron, nickel, cobalt and copper as a catalyst to obtain 3-methylisoquinoline. A nickel catalyst or a stabilized nickel catalyst is preferable as the catalyst. The reaction is preferably carried out in a high boiling point aliphatic hydrocarbon solvent. The solvent is especially preferably a solvent having a boiling point of 150-400°C and a melting point of ≤20°C, such as n-decane, n-undecane, dodecane, cyclododecane or decalin. The reaction is performed under conditions comprising 180-300°C, 5-40kg/cm2 and 0.5-30hr. The 3-methylisoquinoline is important as an intermediate for medicines, agricultural chemicals, dyestuffs, etc.
Inventors:
Mitamura, Shuichi
Katayama, Atsuhiko
Katayama, Atsuhiko
Application Number:
JP7223794A
Publication Date:
May 17, 2004
Filing Date:
April 11, 1994
Export Citation:
Assignee:
NIPPON STEEL CHEM CO LTD
NIPPON STEEL CORP
NIPPON STEEL CORP
International Classes:
C07D217/02; B01J23/74; B01J25/00; C07B61/00; (IPC1-7): C07D217/02; B01J23/74; B01J25/00
Attorney, Agent or Firm:
成瀬 勝夫 （外１名）
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