Title:
Liangtoujian抽出物の製造方法、その抽出物を含有する医薬組成物及びその用途
Document Type and Number:
Japanese Patent JP2004518751
Kind Code:
A
Abstract:
The present invention discloses a method for preparing Anemone Raddeana extract, comprising the following steps: a) pulverizing a rhizome, stem, leaf, flower, and fruit of Anemone Raddeana to obtain crude powders of Anemone Raddeana; b) extracting the crude powders of Anemone Raddeana with an ethanol solution, filtering, and recovering the ethanol; c) absorbing by a macroporous absorbing resin, removing pigments and saccharides, then eluting the resin until colorless with water or aqueous alkali solution, thus the fraction of saponin is retained in tile column; d) eluting with 50~70% ethanol, recovering tile ethanol, adding gelatin, filtering precipitate, decoloring with decolor macroporous resin, eluting with 50~70% ethanol, recovering the ethanol, concentrating and drying to obtain crude saponins of Anemone Raddeana. The present invention further relates to a method for extracting Raddeanin A. The method of the invention is convenient and suitable for industrial production. The Anemone Raddeana extract of the invention is formulated to pharmaceutical composition with pharmaceutically acceptable carriers. The pharmaceutical composition is used for treating malignant neoplasm diseases.
Inventors:
Liu Taiyu
Liu Datong
Daegu
Zhang
Lee Hongshin
Liu Geifeng
Liu Datong
Daegu
Zhang
Lee Hongshin
Liu Geifeng
Application Number:
JP2002567328A
Publication Date:
June 24, 2004
Filing Date:
January 16, 2002
Export Citation:
Assignee:
Changchun Medical School
International Classes:
A61K31/4745; A61K36/00; A61K36/71; A61P35/00; C07G3/00; C07J63/00; (IPC1-7): A61K35/78; A61K31/4745; A61P35/00
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro