Title:
N-アリールアクリダンカルボン酸誘導体の製造方法及びその合成中間体
Document Type and Number:
Japanese Patent JP2004517924
Kind Code:
A
Abstract:
Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermediates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridancarboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.
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Inventors:
Hashem Akhavan-Tufte
Robert A. Eikholt
Richard S Handley
Robert A. Eikholt
Richard S Handley
Application Number:
JP2002559398A
Publication Date:
June 17, 2004
Filing Date:
December 07, 2001
Export Citation:
Assignee:
Lumigen Incorporated
International Classes:
C07B61/00; C07D219/02; C07D219/04; C07D219/06; C07D219/08; C07D401/04; C07D417/04; (IPC1-7): C07D219/04; C07D417/04
Attorney, Agent or Firm:
Ichiro Honda
Keiko Honda
Keiko Honda