Title:
γδT細胞を製造するための方法
Document Type and Number:
Japanese Patent JP4445268
Kind Code:
B2
Abstract:
Preparing a composition of gamma-delta-T lymphocytes (A) comprises: (1) at least one culture stage of a biological preparation containing at least 50 million mononucleated cells, in the presence of a synthetic activator (I) of (A), at the start of culture; and (2) subsequent culture in presence of a cytokine (II). An Independent claim is also included for in vitro or ex vivo culture of blood cells containing more than 10 to the power of 8 (A) where at least 80% of cells are (A).
Inventors:
Romanée, Francois
La Place, Catherine
La Place, Catherine
Application Number:
JP2003569814A
Publication Date:
April 07, 2010
Filing Date:
February 21, 2003
Export Citation:
Assignee:
INNATE PHARMA
International Classes:
C12N5/0783; A61K35/14; A61K35/16; A61K38/00; A61P29/00; A61P31/00; A61P33/00; A61P35/00; A61P37/00; A61P37/04; A61P37/08; A61K35/12
Foreign References:
| WO2000012516A1 |
Other References:
Human Immunology,1997年,Vol.58,pp.70-82
Blood,2000年,Vol.96, No.2,pp.384-392
J. Biol. Chem.,2001年,Vol.276, No.21,18337-18344
FASEB J.,2000年,Vol.14,pp.1669-1670
J. Med. Chem.,2002年 6月,Vol.45,pp.4868-4874
Blood,2000年,Vol.96, No.2,pp.384-392
J. Biol. Chem.,2001年,Vol.276, No.21,18337-18344
FASEB J.,2000年,Vol.14,pp.1669-1670
J. Med. Chem.,2002年 6月,Vol.45,pp.4868-4874
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda