Title:
アミノアルコールおよびその誘導体の製造方法
Document Type and Number:
Japanese Patent JP4335314
Kind Code:
B2
Abstract:
Microorganisms (A), or their enzymatic extracts, able to utilise cyclopentene derivatives (VII) as sole carbon (or carbon and nitrogen) source are new. R1 = 1-4C alkyl or alkoxy, or aryl or aryloxy. Also new are (1) N-acetylamino-alcohol hydrolases (NAAH) from (A) able to hydrolyse (VII), and their functionally equivalent variants or mutants; (2) production of (1R,4S) and/or (1S,4R)-1-amino-4-hydroxymethyl-2-cyclopentene (II), or their derivatives N-substituted by COR1, by reacting (VII) with at least one of (A), its enzymatic extract, NAAH and penicillin G acylase.
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Inventors:
Bearnegger-Egli, Christine
Birch, Owen m.
Bossard, Pierre
Frieden, Walther
Brooks, Frank
Burgdorf, Knut
Duke, Laurent
Ketter-Sarah
Guggisberg, Eve
Birch, Owen m.
Bossard, Pierre
Frieden, Walther
Brooks, Frank
Burgdorf, Knut
Duke, Laurent
Ketter-Sarah
Guggisberg, Eve
Application Number:
JP54163097A
Publication Date:
September 30, 2009
Filing Date:
May 30, 1997
Export Citation:
Assignee:
Lonza A-ge
International Classes:
C12N9/80; C07C215/42; C07C231/08; C07C233/23; C07D209/52; C12N1/20; C12N1/21; C12P13/00; C12P13/02; C12P41/00; C07B57/00; C07C213/02; C12R1/01
Other References:
Expression of the Arthrobacter viscosus penicillin G acylase gene in Escherichia coli and Bacillus subtilis., Appl Environ Microbiol. , 1989年, Vol. 55(6), p. 1351-1356
Molecular cloning of the penicillin G acylase gene from Arthrobacter viscosus., Appl Environ Microbiol. , 1988年, Vol. 54(11), p. 2603-2607
Cloning and sequencing of the pac gene encoding the penicillin G acylase of Bacillus megaterium ATCC 14945,, FEMS Microbiol Lett. , 1995年, Vol. 125(2-3), p. 287-292
Nucleosides & Nucleotides, 1990年, Vol. 9(7), p. 875-884
Purification and properties of ampicillin acylase from Pseudomonas melanogenum., Biochim Biophys Acta. , 1990年, Vol. 1040(1), p. 12-18
Changing the substrate specificity of penicillin G acylase from Kluyvera citroprophila through selective pressure., Biochem J. , 1994年, Vol. 303(Pt3), p. 869-875
Molecular characterization of the 4-hydroxyphenylacetate catabolic pat hway of Escherichia coli W: engineering a mobile aromatic degradative cluster., J Bacteriol. , 1996年 1月,Vol. 178(1), p. 111-120
Expression and regulation of the penicillin G acylase gene from Proteus rettgeri cloned in Escherichia coli., J Bacteriol., 1986年, Vol. 168(1), p. 431-433
Molecular cloning of the penicillin G acylase gene from Arthrobacter viscosus., Appl Environ Microbiol. , 1988年, Vol. 54(11), p. 2603-2607
Cloning and sequencing of the pac gene encoding the penicillin G acylase of Bacillus megaterium ATCC 14945,, FEMS Microbiol Lett. , 1995年, Vol. 125(2-3), p. 287-292
Nucleosides & Nucleotides, 1990年, Vol. 9(7), p. 875-884
Purification and properties of ampicillin acylase from Pseudomonas melanogenum., Biochim Biophys Acta. , 1990年, Vol. 1040(1), p. 12-18
Changing the substrate specificity of penicillin G acylase from Kluyvera citroprophila through selective pressure., Biochem J. , 1994年, Vol. 303(Pt3), p. 869-875
Molecular characterization of the 4-hydroxyphenylacetate catabolic pat hway of Escherichia coli W: engineering a mobile aromatic degradative cluster., J Bacteriol. , 1996年 1月,Vol. 178(1), p. 111-120
Expression and regulation of the penicillin G acylase gene from Proteus rettgeri cloned in Escherichia coli., J Bacteriol., 1986年, Vol. 168(1), p. 431-433
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Tetsuya Kazama
Katsumura Hiro
Shoji Kawai
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Tetsuya Kazama
Katsumura Hiro
Shoji Kawai
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen