Title:
METHOD FOR PRODUCING AMINOALCOHOL DERIVATIVE AND (1R, 4S)-4-[(2-AMINO-6-CHLORO-5-FORMAMIDO-4-PYRIMIDINYL)AMINO]-2-CYCLOPENTENYL-1-METHANOL THEREOF
Document Type and Number:
Japanese Patent JP2009221215
Kind Code:
A
Abstract:
To provide a new method for producing a racemic body or an optically active body of an aminoalcohol of formula I, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, a method for further converting it to the corresponding acyl derivative thereof, and a method for further converting it to (1S, 4R)- or (1R, 4S)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentenyl-1-methanol.
In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, to give (1S, 4R)- or (1R, 4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol.
Inventors:
BRIEDEN WALTER DR
SCHROEER JOSEF DR
BERNEGGER-EGLI CHRISTINE
URBAN EVA-MARIA
PETERSEN MICHAEL DR
RODUIT JEAN-PAUL
BERCHTOLD KATJA
BREITBACH HOLGER DR
SCHROEER JOSEF DR
BERNEGGER-EGLI CHRISTINE
URBAN EVA-MARIA
PETERSEN MICHAEL DR
RODUIT JEAN-PAUL
BERCHTOLD KATJA
BREITBACH HOLGER DR
Application Number:
JP2009125242A
Publication Date:
October 01, 2009
Filing Date:
May 25, 2009
Export Citation:
Assignee:
LONZA AG
International Classes:
C07C213/00; C07B53/00; C07D473/40; C07B55/00; C07B57/00; C07C213/02; C07C213/08; C07C213/10; C07C215/42; C07C233/23; C07C271/24; C07C275/64; C07D473/00; C07D473/02; C07D473/32; C12P13/00; C12P41/00; C07C215/26
Domestic Patent References:
| JPH0892252A | 1996-04-09 |
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Tetsuya Kazama
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Tetsuya Kazama
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