Title:
アゼチジン-2-カルボン酸及びその中間体の製造方法
Document Type and Number:
Japanese Patent JP4294738
Kind Code:
B2
Abstract:
The present invention has its object to provide a process for producing azetidine-2-carboxylic acid and an intermediate thereof, which is efficient and economical and suited for industrial practice. The present invention is related to a process for producing azetidine-2-carboxylic acid of the following formula (5), which comprises subjecting a 4-oxo-2-azetidinecarboxylic acid derivative represented by the general formula (1) to hydride reduction to give azetidine-2-methanol of the following formula (2), treating the same with an amino-protecting agent to give N-protected azetidine-2-methanol represented by the following general formula (3), treating this with an oxidizing agent to give N-protected azetidine-2-carboxylic acid represented by the following general formula (4) and, further, subjecting the amino-protecting group thereof to elimination.
Inventors:
Hiroshi Awaji
Shingo Matsumoto
Kenji Inoue
Kazuhiko Matsuo
Shingo Matsumoto
Kenji Inoue
Kazuhiko Matsuo
Application Number:
JP54547998A
Publication Date:
July 15, 2009
Filing Date:
April 24, 1998
Export Citation:
Assignee:
Kaneka Corporation
International Classes:
C07D205/04
Domestic Patent References:
| JP49014457A | ||||
| JP59130861A | ||||
| JP59161354A | ||||
| JP61238991A | ||||
| JP62081367A | ||||
| JP61115082A | ||||
| JP11510478A |
Other References:
BIAGGIO,F.C. et al, The synthesis of a new 8-azaprostanoid, Journal of Heterocyclic Chemistry, 1989年, Vol.26, No.3, p.725-8
RODEBAUGH,R.M. et al, Facile new synthesis of DL-azetidine-2-carboxylic acid, Journal of Heterocyclic Chemistry, 1969年, Vol.6, No.3, p.435-7
Chem. Abstr., Vol.51 (1957) 抄録番号第51:17208, 1957年, & FOWDEN,L., Azetidine-2-carboxylic acid: a new cyclic imino acid occurring in plants, Biochemical Journal, 1956, Vol.64, p.323-332
RODEBAUGH,R.M. et al, Facile new synthesis of DL-azetidine-2-carboxylic acid, Journal of Heterocyclic Chemistry, 1969年, Vol.6, No.3, p.435-7
Chem. Abstr., Vol.51 (1957) 抄録番号第51:17208, 1957年, & FOWDEN,L., Azetidine-2-carboxylic acid: a new cyclic imino acid occurring in plants, Biochemical Journal, 1956, Vol.64, p.323-332
Attorney, Agent or Firm:
Atomi International Patent Office
Yasuo Yasutomi
Shinya Furuya
Yasuo Yasutomi
Shinya Furuya