Title:
アゼチジニルメトキシピリジン誘導体の製造方法及びその使用
Document Type and Number:
Japanese Patent JPWO2011040574
Kind Code:
A1
Abstract:
式（ＸＩ）の化合物又はその塩と式（ＩＩ）の化合物とを反応させて式（ＸＩＩＩ）のアゼチジニルメトキシピリジン誘導体又はその塩を得ること、該得たものとキレート化合物とを反応させて式（ＸＩＶ）の化合物又はその塩を得ること、及び、該得たものとレニウム化合物、放射性テクネチウム化合物又は放射性レニウム化合物若しくはそれらの塩とを反応させることを含む、式（ＸＶ）のアゼチジニルメトキシピリジン誘導体の簡便な製造方法の提供。Ｐ１：保護基、Ｘ０：結合，−（ＣＨ２）１−６−，−Ｃ≡Ｃ−（ＣＨ２）１−６−等、Ａ１，２：Ｍｅ，ｉＰｒ、Ｐ２：Ｈ，保護基Ｌ０：キレート部、Ｚ０：Ｒｅ，９４ｍ／９９／９９ｍＴｃ，１８６／１８８Ｒｅ
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Inventors:
Eiji Saji
Hiroyuki Kimura
Masahiro Ono
Hidekazu Kawashima
Daisuke Mori
Naoya Harada
Hiroyuki Kimura
Masahiro Ono
Hidekazu Kawashima
Daisuke Mori
Naoya Harada
Application Number:
JP2011534335A
Publication Date:
February 28, 2013
Filing Date:
September 30, 2010
Export Citation:
Assignee:
Kyoto University
International Classes:
C07D401/12; A61K51/00; C07D401/14; C07F13/00
Domestic Patent References:
| JPH11514368A | 1999-12-07 | |||
| JP2008546783A | 2008-12-25 |
Foreign References:
| WO2005000806A2 | 2005-01-06 | |||
| WO2008060378A2 | 2008-05-22 | |||
| EP1908761A1 | 2008-04-09 |
Other References:
MUTAT. RES., (1997), 376, [1-2], P.61-70, JPN6010003425, ISSN: 0002875665
SIHVER,W. ET AL: "Synthesis and characterization of binding of 5-[76Br]bromo-3-[[2(S)-azetidinyl]methoxy]pyridine, a n", JOURNAL OF NEUROCHEMISTRY, vol. 73, no. 3, JPN6010061376, 1999, pages 1264 - 1272, ISSN: 0002875666
HORTI,A.G. ET AL: "Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a", NUCLEAR MEDICINE AND BIOLOGY, vol. 26, no. 2, JPN6010061377, 1999, pages 175 - 182, XP004157107, ISSN: 0002875667, DOI: 10.1016/S0969-8051(98)00086-9
KOREN,A.O. ET AL: "2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, Affinity for Nicotinic Acetylchol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 19, JPN6010061378, 1998, pages 3690 - 3698, ISSN: 0002875668
DIZIO,J.P. ET AL: "Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential", BIOCONJUGATE CHEMISTRY, vol. 2, no. 5, JPN6010061379, 1991, pages 353 - 366, ISSN: 0002875669
第4版 実験化学講座20, vol. 第3刷, JPN6010061380, 1996, pages 284 - 288, ISSN: 0002875670
第5版 実験化学講座13, JPN6010061381, 2004, pages 298 - 302, ISSN: 0002875671
SIHVER,W. ET AL: "Synthesis and characterization of binding of 5-[76Br]bromo-3-[[2(S)-azetidinyl]methoxy]pyridine, a n", JOURNAL OF NEUROCHEMISTRY, vol. 73, no. 3, JPN6010061376, 1999, pages 1264 - 1272, ISSN: 0002875666
HORTI,A.G. ET AL: "Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a", NUCLEAR MEDICINE AND BIOLOGY, vol. 26, no. 2, JPN6010061377, 1999, pages 175 - 182, XP004157107, ISSN: 0002875667, DOI: 10.1016/S0969-8051(98)00086-9
KOREN,A.O. ET AL: "2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, Affinity for Nicotinic Acetylchol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 19, JPN6010061378, 1998, pages 3690 - 3698, ISSN: 0002875668
DIZIO,J.P. ET AL: "Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential", BIOCONJUGATE CHEMISTRY, vol. 2, no. 5, JPN6010061379, 1991, pages 353 - 366, ISSN: 0002875669
第4版 実験化学講座20, vol. 第3刷, JPN6010061380, 1996, pages 284 - 288, ISSN: 0002875670
第5版 実験化学講座13, JPN6010061381, 2004, pages 298 - 302, ISSN: 0002875671
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners
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