Title:
METHOD FOR PRODUCING BENZOAZEPINE DERIVATIVE AND INTERMEDIATE THEREOF
Document Type and Number:
Japanese Patent JP2022055368
Kind Code:
A
Abstract:
To provide a novel production method capable of efficiently producing an optically active N-[(S)-1-hydroxypropane-2-yl]-4-methyl-1-[2-methyl-4-(3-methyl-1H-pyrazole-1-yl)benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxamide.SOLUTION: There is provided a method for producing (R)-4-methyl-1-(2-methyl-4-(3-methyl-1H-pyrazole-1-yl))benzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester by methylating 1-(2-methyl-4-(3-methyl-1H-pyrazole-1-yl)benzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl by a methylating agent in the presence of a specific asymmetric quaternary ammonium salt and a base in an organic solvent.SELECTED DRAWING: None
Inventors:
NAGAI KAZUSHIGE
KUNO YUKA
KATAOKA HIROYO
KUNO YUKA
KATAOKA HIROYO
Application Number:
JP2019026983A
Publication Date:
April 08, 2022
Filing Date:
February 19, 2019
Export Citation:
Assignee:
SANWA KAGAKU KENKYUSHO CO
International Classes:
C07D223/16; B01J23/44; B01J31/02; C07D403/10