To provide a biphenyl derivative by a simple and industrially excellent technique with good selectivity and efficiency without passing through an expensive synthetic intermediate by using an inexpensive and industrially readily available starting substrate and reagent.
A method for producing the biphenyl derivative comprises subjecting an aromatic chloride as the starting substrate to a coupling reaction with a triarylphosphine ligand in the presence of a nickel catalyst and a metal reducing agent to afford a dimethylbiphenyl compound. The method for producing the biphenyl derivative comprises further subjecting the resultant dimethylbiphenyl compound to a chlorination reaction and a fluorination reaction to provide a bis(trifluoromethyl)biphenyl compound.
ICHINOSE YUTAKA
NAKATANI NIRO
