Title:
METHOD FOR PRODUCING CLAVULANIC ACID
Document Type and Number:
Japanese Patent JP3507067
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide an intermediate and a reaction in the process of converting it to clavulanic acid.
SOLUTION: This method for producing clavulanic acid is a method for β-hydroxylating a compound having an amino, guanidino or amidino group in the side chain of an α-amino acid substrate and expressed by formula 1 [wherein, R1 is expressed by formula 2 (wherein, R2 is H or a 1-6C alkyl)], an α-amino acid or its N-acyl derivative, and is characterized by performing the hydroxylation reaction by incubating the substrates together with a carbamic acid synthase.
Inventors:
Keith Howard Bulgari
Neville Hubert Nicholson
Stephen William Elson
Jeffrey Edwards
Allison Jane Earl
William Henry Holms
David Michael Mousedale
Jack Edward Baldwin
Christopher Scofield
Neville Hubert Nicholson
Stephen William Elson
Jeffrey Edwards
Allison Jane Earl
William Henry Holms
David Michael Mousedale
Jack Edward Baldwin
Christopher Scofield
Application Number:
JP2003140429A
Publication Date:
March 15, 2004
Filing Date:
May 19, 2003
Export Citation:
Assignee:
SmithKline Beechham Public Limited Company
International Classes:
C12N15/09; C07C257/14; C07C279/14; C07D205/08; C07D503/00; C12N9/06; C12N9/14; C12N9/70; C12N9/78; C12N15/00; C12N15/57; C12P17/10; C12P17/18; C12R1/465; (IPC1-7): C12P17/10; C07D205/08
Other References:
Ｂｉｏｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．２９，Ｎｏ．２７（１９９０）ｐ．６４９９−６５０８
Ｂｉｏｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．３０，Ｎｏ．８（１９９１）ｐ．２２８１−２２９２
Ｂｉｏｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．３０，Ｎｏ．８（１９９１）ｐ．２２８１−２２９２
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)