Title:
アビバクタムナトリウムの結晶形Ｃの製造方法
Document Type and Number:
Japanese Patent JP7072002
Kind Code:
B2
Abstract:
The invention relates to a process for the preparation of avibactam sodium in polymorphic form C comprising the steps (i) providing a mixture comprising avibactam or a salt thereof and a solvent, wherein the mixture has a water content of less than 2% by weight based on the weight of the mixture; (ii) increasing the temperature of the mixture provided in (i) to at least 55° C. and providing a positive pressure; adding a sodium source to the mixture in step (i) and/or (ii) if the form of avibactam provided in (i) is not avibactam sodium; thereby obtaining avibactam sodium in polymorphic form C.
Inventors:
Michael fischer
Bernica, Veronica
Lechner, Andreas
Stagle, brigitte
Bernica, Veronica
Lechner, Andreas
Stagle, brigitte
Application Number:
JP2019563686A
Publication Date:
May 19, 2022
Filing Date:
February 07, 2018
Export Citation:
Assignee:
SANDOZ AKTIENGESELLSCHAFT
International Classes:
C07D471/08
Domestic Patent References:
| JP2014517027A | ||||
| JP2013507346A | ||||
| JP2016510062A |
Attorney, Agent or Firm:
Kawaguchi International Patent Office